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Janumet contains a combination of metformin and sitagliptin. Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. Janumet is used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. Janumet is not for treating type 1 diabetes.