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Diovan HCT Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Valsartan is an angiotensin II receptor antagonist. Valsartan keeps blood vessels from narrowing, which lowers blood pressure improves blood flow. The combination of hydrochlorothiazide and valsartan is used to treat high blood pressure (hypertension).